Post-transcriptional Regulation of Gene Expression in Inflammation, Hepatotoxicity, and Cancer
Innate immunity is a highly conserved response that quickly detects and attempts to clear pathogens and harmful environmental stimuli by inducing inflammatory responses. These responses are orchestrated via temporal and highly coordinated regulation of a number of genes. In addition to regulation at the transcriptional level, a majority of these genes are also regulated by post-transcriptional mechanisms that modify mRNA stability and/or translation. The focus of our research is to understand the association between environmental stimuli, post-transcriptional mechanisms of gene expression, and disease pathogenesis. We are specifically interested in:
1) Investigating how post-transcriptional mechanisms of gene expression regulate the pathogenesis of acute lung injury/acute respiratory distress syndrome.
2) Understanding the biochemical mechanisms of hepatotoxicity and carcinogenesis in the context of post-transcriptional regulation of gene expression.