Post-transcriptional Regulation of Gene Expression in Inflammation 

Innate immunity is a highly conserved response that quickly detects and attempts to clear pathogens and harmful environmental stimuli by inducing inflammatory responses. These responses are orchestrated via temporal and highly coordinated regulation of a number of genes. In addition to regulation at the transcriptional level, a majority of these genes are also regulated by post-transcriptional mechanisms that modify mRNA stability and/or translation. The focus of our research is to understand the association between environmental stimuli, post-transcriptional mechanisms of gene expression, and disease pathogenesis. We are specifically interested in:

Investigating how post-transcriptional mechanisms of gene expression regulate the pathogenesis of acute lung and liver injury induced by environmental agents.

We are studying Tristetraprolin (TTP) family of RNA binding proteins. TTP or ZFP36 is encoded by ZFP36 gene in humans. The other two members in humans include ZFP36L1 and ZFP36L2 encoded by ZFP36L1 and ZFP36L2 genes respectively.